Some medicines work by activating or blocking receptors on the surface of cells.
Surprisingly, we didn't observe any significant changes in FASN protein levels either by activating or blocking of the AKT pathway.
While the previous viruses report Wnt signaling levels in a variety of settings, activating or blocking the Wnt pathway is often essential in studies on cell proliferation, differentiation and survival.
Therefore, activating or blocking specific S1P receptors may be a more promising approach to alleviate sepsis symptoms than simply increasing S1P blood concentrations.
Typical in vitro studies involve stimulating or activating cells, blocking signaling pathways and observing disease-relevant gene expression or proliferative outcomes.
We found that Salmonella infection caused dramatic changes in gene expression of colon mucosa, which further leads to a sequence of cellular events that involve activating and blocking signaling modulation responses in colon mucosa.
We have shown here that in ovarian cancer cells, NF-κB is constitutively activated, and blocking NF-κB activation with ginger results in suppressed production of NF κB regulated angiogenic factors and selectively inhibits ovarian cancer cell growth.
Furthermore, activating GSK3 blocked insulin's ability to increase epiblast cell number without affecting the epiblast cell number of embryos cultured without insulin, replicating the effect of PI3K inhibition.
She would use a transcription factor to activate or block neural activity in different subsets of neurons, then observe behavioral changes in the adult flies.
These promising results could open new avenues for the identification of novel genes for a general definition of MO/macrophage activation patterns and for pathways activated or blocked during different stages of the disease or therapy-induced remission in RA.
This refinement, which became known as quantitative structure-activity relationship, simplified the search for chemical structures that could activate or block various drug receptors.
