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This indicates that berberine could suppress constitutive activation of STAT3 in NPC cells and inhibited their survival ability by activating apoptosis.
Mechanistic study revealed that compound 8c enhanced reactive oxygen species level by inhibiting TrxR and then induced apoptosis by activating apoptosis proteins, bax and cleaved-caspase 3 in HCT116 cells.
Revealing a relationship between azabicycloalkanone and aza peptide mimics, novel AVPI mimics were synthesized which exhibit utility for studying structure activity relationships to develop leads for activating apoptosis in cancer cells.
JHMV can also induce apoptosis without viral replication through spike glycoprotein and FAS interactions [24], [27], therefore JHMV may also be activating apoptosis in the absence of viral replication.
The caspase family of proteins has a dominant role in activating apoptosis [ 29].
Yet, melanoma tumor cells have developed mechanisms to block BID/BIM from activating apoptosis following treatment.
Similar(32)
Betulin and its derivatives induced apoptosis by activating apoptosis-related genes.
This result suggested that JZ534 may induce apoptosis by activating apoptosis-related proteins.
The results indicated that JZ534 induced lung cancer cell apoptosis by activating apoptosis-related proteins.
This second TA domain is incapable of activating apoptosis-related genes and is regulated differentially throughout the cell cycle.
Most cytotoxic drugs, which activate apoptosis, lead to the activation of the mitochondrial pathway.
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