During the next two-hour period, IRF3, p65 and p50 were activated and interacted to regulate gene expression, as were JUN and FOS as well as CREB1.
It activates and interacts with the serine/threonine kinase 11/liver kinase (B1STK11/LKB1), which catalyzes the process of phosphorylation to activate AMP-activated protein kinase (AMPK), thus plays a role in the regulation of food intake [ 44, 45].
Moreover, SOS2 also works to activate and interact with vacuolar N+/H+ and H+/Ca2+ antiporters and V-ATPase, which will contribute to sequestration of excess Na+ ions, further resulting in Na+ ion homeostasis.
When bound to GDP, RABs are inactive, but when bound to GTP, they become activated and interact with several effector proteins (Ung et al. 2013), including SNAREs, during the tethering of cargo at post-Golgi compartments (Cai et al. 2007).
Thus, Vav protein is activated and interacts with substrate proteins, and the PH domain is exposed for PIP3 binding [ 6].
From UNM to BCP stage, AT5G04760 is activated and interacts with SUVR2 to regulate their downstream gene expression.
GTP-bound Rabp is then activated and can interact with its effectors.
During this process, promutagens and procarcinogens could be activated and could interact with proteins as well as DNA to form adducts.
The importance of the carboxy-terminal motifs in these TFs function has been deeply analysed, indicating that the mutation of individual amino acids in these motifs significantly affect their ability to activate and to interact with proteins of the basal transcriptional machinery [ 26].
Activated pDCs and interacting T cells may contribute significantly to the inflammatory environment in RA.
