Sentence examples for activating activity of from inspiring English sources

The strategy is validated by using it to control the sulfonation and estrogen receptor (ER) activating activity of raloxifene (a US Food and Drug Administration-approved selective estrogen receptor modulator) and its derivatives.

Control digests of plasmid DNA confirmed that the DNAse was active and could abolish the inflammasome activating activity of plasmid DNA (Fig. 5A).

Therefore, we hypothesized that the expression level of REST in undifferentiated NG108 is controlled by the competition between the activating activity of Sp1 and the repressive activity of another Sp factor.

In addition we found that R97 and Y105, located on the other side of the DD, can be of major importance for a large part of the NF-κB activating activity of IRAK-M.

However, combined R97/Y105 mutation reduced NF-κB to the level of the death domain deletion mutant which identifies these residues as a second crucial binding site for the NF-κB activating activity of IRAK-M in 293T cells.

Zhou et al. [ 13] showed that W74 is involved in IRAK-4 binding and NF-κB activating activity of IRAK-M when macrophages are stimulated with a viral type TLR7 agonist.

In contrast, FKBP59 failed to stimulate the ATPase activity of Hsp90, although it could stimulate the GR ligand-binding domain activated activity of Hsp90 [47].

TNF-α can activate activity of osteoclasts and accelerate absorption of the bone and cartilage and induce occurrence of oxygen free radicals an d lipid peroxidation, which can induce ischemic necrosis of the femoral head [ 30].

The plasminogen-activating activity of streptokinase has been implicated in the accelerated clearance of host fibrin, which may promote the dissemination of S. pyogenes in host tissues.

To study the effect of pH on the resistance-activating activity of mycelial extract, the pH value was adjusted from the original 6.7 to 4 with 1 N HCl or to 10 with 1 N KOH.

The resistance-activating activity of the mycelium extract was not affected by treatment with either cation or anion exchange resins, indicating that none of the active components have positive or negative charges on their molecules.