Sentence examples for activating a target from inspiring English sources
We first tested whether the mutant GATA3 from MCF7 cells (mutGATA3) was capable of activating a target gene.
In case of simulation of the effect of activating a target gene, its expression level values may be increased to the desired value.
These results support a mechanism of transformation whereby two oncogenic fusion proteins cooperate by activating a target gene and then modulating the function of its downstream product.
Furthermore, the PTE also demonstrates anti-insulator activity by enabling the IAB5 enhancer to bypass an insulator from the BX-C to activate a target promoter on transgenes [17].
Since the GR ligand type can determine the precise set of target genes activated, novel ligands might activate a target gene spectrum that results in better GC treatment efficiency and tolerability, reducing side effects such as diabetes or glaucoma.
Therefore, the tissue-specific or stress-specific induction or repression of a miRNA gene may downregulate or activate a target gene independently of TFs that target the same gene.
(ii) Source target Pairs versus Targets determines whether a target's connectivity is evaluated separately for every source (i.e. each source activates a target differently) or if a target is considered to be disconnected only when it is no longer reachable from any source (i.e. any source can activate the target).
Furthermore, domain exchange experiments indicated that the ability to activate a target gene was not conferred by exchange of the basic-helix loop helix sequences previously implicated in DNA-basic-helix loop helix1996).
Thus SOX9 interacts with the gene for a coactivator, which cooperates with SOX9 in activating a downstream target of SOX9.
It is well known that the transcription factor IRF1 exerts multiple effects by activating a set of target genes, depending on the cell type and on the specific stimuli.
Alternately, a common TF (p53 in this case) can activate a downstream target gene and also a miRNA which then suppresses the downstream target gene.
