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The phrase "activating a handful of" is correct and usable in written English.
It can be used when referring to the process of initiating or enabling a small number of items, features, or elements.
Example: "The software update includes a feature for activating a handful of new tools that enhance user experience."
Alternatives: "enabling a few" or "turning on several".
Exact(1)
By activating a handful of genes, they turn the developmental clock backward in adult cells, converting them into an embryolike state.
Similar(59)
Any given smell typically activates a handful of the 1000 olfactory receptors, and only activates the subset of olfactory receptor neurons that express those receptors, Axel, Buck, and others found.
The oncogenic potential of MMTV thus became largely explainable through the ability of the virus to activate Wnt1 or a handful of alternative proto-oncogenes [ 6].
Although the trends in the spleen data may suggest some activated immune responses, there were only a handful of immune-function genes with consistent signature of increased expression, and robust statistical statements are precluded by the lack of replication for the spleen chip.
"A handful" of RelayRides vehicles have OnStar activated, he said.
A handful of carbon.
A handful of happy experiences.
A handful of players watched.
I never eat a handful of ladybugs.
Only a handful of Democrats will defect.
Howard made a handful of strong saves.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com