DAG activates two interdependent pathways: direct activation of Munc13 via its C1 domain and PKC dependent phosphorylation of Munc18.
TGF-β1 activates two independent signal pathways, which lead to the activation of different transcription factors [ 49].
BMP binding either to a single receptor type subunit followed by the recruitment of the second subunit or to a pre-existing loose complex of both receptor types, activates two downstream signalling cascades: 1) SMAD proteins or 2 p388 mitogen activated protein kinase (p38MAPK) pathways [13].
Binding of LPS to the TLR4 complex of the host activates two signaling cascades via different adaptor proteins leading to the activation of two main transcription factors: NFκB, a key transcription factor regulating pro-inflammatory genes, and interferon (IFN) regulatory factor 3 (IRF3), which induces IRF3-responsive genes, most prominently IFNβ.
TNFα binds to and activates two receptors TNF-R1 and TNF-receptors TNF-R1me of their andivaTNF-R2 ands TNF-R2 andathee levels outcomeulatiof of their mactivationys: a pro-apoptotic pathingesa pronnecroptheic pathway, and a cell-surelativeathway (Vanden Berghe et alevels4).
In this code, the Main class creates and activates two Box threads (lines 3 4).
Upon release, CRF activates two G protein-coupled receptors (GPCRs): CRF receptor 1 (CRFR1) and CRF receptor 2 (CRFR2).
Images of normal brains have shown that disgust activates two particular regions: a part of the cortex called the insula and a subcortical region, the putamen.
Furthermore, Bae and Jung [3] developed service robots, KOBOKER shown in Fig. 5, that is able to self-balance using up and down sliding mechanism that activates two arms in order to perform tasks on the floor.
AcpS, a 4-phosphopantetheinyl transferase, activates two distinct acyl carrier proteins (ACPs) that are present in fatty acid synthase (FAS) systems FAS-I and FAS-II, the ACP-I domain and the mycobacterial ACP-II protein (ACPM), respectively.
This intronic mutation, which segregates in a dominant and fully penetrant manner over three generations, abolishes normal LHX4 splicing and activates two exonic cryptic splice sites, thereby predicting two different proteins deleted in their homeodomain sequence.
