Sentence examples for activates the alternative from inspiring English sources

This protein activates the alternative complement pathway thereby strengthening unspecific immune defence mechanisms.

Of relevance, in functional studies, the R102G variant activates the alternative pathway more efficiently than the wild-type protein.

Properdin activates the alternative pathway of complement by assembling the C3 convertase on target surfaces (Kemper and Hourcade, 2008).

The increase in renal medullary ammonia level resulting from the stimulation of ammonia production by metabolic acidosis activates the alternative complement pathway and causes progressive tubulointerstitial injury [ 21].

As it has been shown by Gadd and Reid [ 23] antigen-bound rabbit IgG activates the alternative pathway (in human serum).

In addition to the acquired immune response, there also exists an innate immune response that activates the alternative complement pathway via the MBL pathway.

Similarly, posttranslational modification of p100 by SUMO is a determining factor for stimuli-induced p100 processing, which is the primary step in activating the alternative NF- κB, and blocking SUMOylation of p100 would inhibit ultimate activation of the alternative NF- κB pathway [ 37].

Masp1 has been shown to activate the alternative pathway18 and even to directly cleave C3 (ref. 19).

Because antibodies are not needed to activate the alternative pathway but are required to set off the classical cascade the alternative pathway serves as a first defense against infection and is part of the nonspecific, innate immune response, which occurs before a specific, acquired immune response can be mounted.

It is noteworthy that strains 8612, Y and Gamba 05 activated the alternative pathway less than the other strains analyzed.

The surface of rabbit erythrocytes activated the alternative complement pathway leading to their lysis and release of hemoglobin in the buffer.