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In their active cleaved form, each neurotrophin selectively activates one of three types of Trk receptors (Fig. 1), NGF activates TrkA, NT-3 activates TrkC, while both BDNF and NT-4 activate TrkB receptors (Patapoutian & Reichardt 2001).
In most signaling studies related to Nox enzymes, the cellular response is triggered by a receptor-linked hormone or growth factor that activates one of the Nox isoforms, rather than by oxygen concentration per se.
Furthermore, we exploited the multicolor Confetti reporter system, a powerful tool for clonal analysis, in which Col2a1-Cre ERT-mediated recombination randomly activates one of its four reporters (Supplementary information, Figure S1F).
This means that perturbations in the strength of any individual interaction the extent to which a TF activates one of its target genes will not disturb the state of the network.
The interface isn't intuitive, and it's easy to accidentally brush a part of the screen that activates one of the controls.
When a character activates one of these dresspheres, the other characters are replaced by two controllable support units.
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A surface mosaic of defense and non-defense proteins formed on the microbial surface could activate one of the tissue reactivity programs via a binary code (help or silence) generated by the adsorbed proteins.
A hardware joystick controller on the back lets you activate one of eight customizable sounds, so that you can use a different bell tone for cars and for pedestrians, or even play a pre-recorded message of your own creation — useful for keeping some recorded swears on hand for easy blasting when you get cut off by a taxi in the bike lane.
In [15], a coherent versus non-coherent DF space time shift keying system is proposed where a matrix dispersion approach is used to activate one of the relays similar to activating transmit antennas in SSK.
These factors activate one of the most important transcription factors in the nucleus, activating protein-1 (AP-1), which governs the transcription of key molecules involved in cell cycle progression and survival, as well as oncogene-induced transformation and cancer cell invasion [ 1- 4].
For example, to block the negative effect (path) of ErbB2 on ERK in Figure 2A, one could either cut/inactivate ErbB2, or permanently activate one of the nodes ErbB13, Grb2, SOS, Ras, MEK, or ERK.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com