However, Demott et al. (2010) indicated that n IN,Tk corresponds to the maximum number concentration of ambient IN activated mostly through deposition nucleation, because deposition nucleation is the primary contributor in mixed-phase clouds at temperatures above −35 °C (Phillips et al. 2008).
DENN (differentially expressed in normal and neoplastic cells) domain-containing proteins are RabGEFs that activate mostly endocytotic Rabs (12).
Dendritic segments located in these afferent sparse zones are likely to be activated mostly via intracortical connections that may explain the weak responsiveness of a subset of L5 neurons to single-whisker stimulation (de Kock et al. 2007).
Accordingly, we were able to demonstrate that the effect of DIM treatment on CYP1A1 and GREB1 expression is mediated by ERα, which, in this case, is activated mostly by the PKA signaling pathway.
The canonical NF- κB pathway is activated mostly by the stimulation of proinflammatory receptors, such as the TNF receptor superfamily, the Toll-like receptor family (TLRs), and cytokine receptors for the interleukins [ 88].
In cells, MDA5 is activated mostly, if not only, by >2 kb long viral dsRNA [ 6, 39], higher-order viral RNA structures [ 40] or >0.5 kb of the synthetic dsRNA mimic poly(I C) [ 6].
Rop GTPases are activated mostly by a type of GEF proteins absent in Opisthokonts – the PRONE-GEFs [ 105] - whose activity is regulated by interactions with specific transmembrane Ser/Thr receptor kinases (RLKs; [ 105, 106]).
Both inactivation by Na [which does not involve an interaction with the CBDs (25, 26)] and activation via occupation of CBDs are strongly modulated by binding of the phospholipid PIP2 to cationic sites of the cytoplasmic loop, dubbed the exchanger inhibitory peptide (XIP) domain: PIP2 activates NCX mostly by antagonizing Na-dependent inactivation (27, 28).
Namely, LNHP genes are greatly enriched in activating marks (mostly acetylations), a strong change in acetylation level being observed when repressed.
