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Somehow, this activates massive membrane uptake, and of course, Na/K ATPase as an abundant membrane protein is lost.
In Fig. 7 A we describe that the nonhydrolyzable GTP analog, GTPγS, activates massive endocytosis in WT-expressing cells with free cytoplasmic Ca clamped to 0.1 µM.
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Here's Zynga's official statement when we reached out to them about this: "Our goal with Zynga.org is to activate massive change for good and we're focused on providing people with the largest possible platform to effect positive social change.
In fibroblasts, large Ca transients activate massive endocytosis (MEND) that involves membrane protein palmitoylation subsequent to mitochondrial permeability transition pore (PTP) openings.
These evolutionary events generated new levels of complexity and new ecosystems that probably activated massive radiations of retroviruses and LTR retrotransposons, as well as the emergence of caulimoviruses.
One extremely harmful lesion is the double-strand break (DSB), which activates a massive signaling network – the DNA damage response (DDR).
But when, deep in space, the generator is finally activated, its massive blast of energy tears open the laws of physics and casts the vessel and its crew into an alternate universe.
Upon exposure to DNA damaging agents, Saccharomyces cerevisiae respond by activating a massive transcriptional program that reflects the fact that "DNA damaging" agents also damage other cellular macromolecules.
In bacteria, an SOS-response is activated by massive DNA damage [ 12].
Thus, P2RX7 is likely to be activated by the massive release of ATP during septic shock.
During ureteral obstruction, interstitial fibroblasts are activated resulting in massive proliferation and excessive ECM accumulation.
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