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Furthermore, we note that a key event in the canonical Notch signalling pathway is the release, following ligand activation, of Notch intracellular domain (NICD) and its subsequent transport to the nucleus, where it activates a range of Notch pathway targets.
This is probably due to the fact that F/R activates a range of transcription factors to induce SOCS3 gene expression [8,9], through the activation of ERK and JNK MAP kinase pathways [8,9], whereas SOCS induction in response to 007 appears only to require induction of AP1 activity.
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Plants are continuously subjected to pathogen attack and respond by activating a range of defense mechanisms.
These conditions, however, activate a range of stress response pathways to promote tumor survival and aggressiveness.
Finally, AGEs are able to bind and activate a range of receptors, which then trigger a downstream cascade of pathogenic mediators.
Since then, both HIF-1α and HIF-2α were detected in most human cells, and both activate a range of hypoxia response elements with similar efficacy.
Compared to multiplication problems, subtraction problems activated a range of areas in the frontal and parietal lobe, including the IPS, as well as the basal ganglia.
Thus, the lung contains multiple cell types and exposure to LPS is known to activate a range of intracellular and extracellular pathways.
The most important oxygenase is CYP1A2, but also CYP1A1 and CYP1B1 can activate a range of arylamines to reactive intermediates [ 6].
Flagellins from Gram-negative bacteria undergo a direct interaction with the leucine-rich regions in TLR-5 and activate a range of inflammatory cells via a TLR-5-dependent signaling pathway [ 11, 12].
As an alternative, whole detergent-inactivated influenza virus can be combined with ISCOMs, which can deliver enclosed antigen directly to DCs and activate a range of innate cells, generating a TH1 and CTL response [ 84].
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