Exact(4)
LCO signals are transduced via a common symbiotic signaling pathway (CSSP) that activates a group of GRAS transcription factors (TFs).
ATF-2 forms a homodimer as well as a heterodimer with c-Jun and activates a group of target genes (Hai & Curran 1991; Matsuda et al. 1991).
Stress signaling in response to oxygen/glucose deprivation (OGD) and ischemic injury activates a group of pro-apoptotic genes, the Bcl-2 homology domain 3 (BH3 -only proteins, which are capaBH3 -onlytivating the mitochondrial aproteins pathwhich
ATF4 is a transcriptional factor which senses deficits in protein translation, typically related to ER stress or amino acid limitation, and in turn activates a group of target genes through a consensus ATF4 promoter binding motif (Harding et al., 2003; Su et al., 2009).
Similar(56)
Drugs such as nicotine and cocaine activate a group of dopamine-producing neurons in the VTA.
One possible reason, they discovered, is that calorie restriction and exercise activate a group of genes called sirtuins, which appear to have a direct effect on longevity.
Apoptotic signals, both intracellular and extracellular, converge to activate a group of apoptosis-specific proteases termed caspases, a family of cysteine proteases with specificity for aspartic acid residues in their substrates [8].
As ATF-2 is also activated by hypoxia (Maekawa et al. 2008), it may activate a group of target genes, including the PDGF receptor α, in response to hypoxic stress.
6, 7 Upon ER stress, a variety of human cancers activate a group of signal transduction pathways, inducing cellular stress responses such as the unfolded protein response (UPR) and autophagy to maintain ER homeostasis.
Taken together, these findings demonstrate that Pou3f1 is most likely an intrinsic neural initiation factor that participates in the transition of pluripotent stem cells to NPCs by directly activating a group of key neural fate-promoting genes.
Most data have suggested that LKB1 exerts its physiological effects by phosphorylating and activating a group of 14 related protein kinases that belong to the AMPK (AMP-activated protein kinase) subfamily [ 9].
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