ERK pathway can be activated via the PI3K activation or independent of it, depending on the cell type (41).
Because PTH signaling activates Erk/MAPK [48], an immediate upstream activator of RSK2, ATF4 can be activated via the PTH-MAPK-RSK2 signaling pathway.
Consequently, this system is activated via the classical pathway of complement activation only by those antibodies which, in a first incubation step, have been bound to their target molecules on the donors' cells.
During TCIPA, activated platelets secrete several potent factors, including thromboxane A2 and ADP, activated via the COX-1 and P2Y12 platelet activation pathways respectively, which in turn heightens the process of activation and aggregation.
IP3Rs located at the surface of the ER are often activated via the production of phospholipase C PLCC) following the activation of group I mGluRs.
Subsequently, two functional characteristics of CD4+CD25+ T-Regs were described; anergy, defined by an incapacity to produce IL2 and proliferate when activated via the TCR, and as well, the capacity to actively suppress polyclonal T cell proliferation in vitro, via inhibition of IL2 production by TCR-activated "effector" cells [20].
Given the role of STAT3 in MET-TKI-induced apoptosis in MET-activated cells, we investigated the effect of inhibition of STAT3 activated via the IL-6 JAK IL-6 JAKon apathways.
The speed-limiting tech can be activated via the steering wheel and briefly overridden by pressing firmly on the accelerator.
These reactions need to be activated via the homogeneous catalysis involving a metal complex and a primary alcohol.
When the user requests for a particular visualization of a user-selected dataset, Stormy's plotters are activated via the web application framework to plot the data and returns the images to the user's browser for display.
In vitro experiments demonstrated that CyA-P-CyB was activated via the cleavage of a peptide linker by cathepsin B in tumor cells to produce fluorescence in the NIR region based on a FRET mechanism.
