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An old, but still used, classification of macrophages roughly separates them into two "extreme" polarized subpopulations: the classically activated type 1 macrophages (M1) and the alternative activated type 2 macrophages (M2).
This signaling pathway may involve cAMP production by Ca2+-calmodulin activated type I adenyl cyclase [ 60], cAMP-induced activation of protein kinase A and phosphorylation of the mechanotransduction channel or the myosin motor [ 43].
Type II receptors are constitutively active serine/threonine kinases which trans-phosphorylate type I receptors upon ligand binding; subsequently, activated type I receptors phosphorylate and activate some components of the Smad protein family, Smad1, 5, and 8, called BMP receptor-regulated Smads (BR-Smads) [ 1– 3].
EcDefensin activated type I IFN and Interferon-sensitive response element (ISRE) in vitro.
Two major polarization states have been described for macrophages, the classically activated type 1 (M1) and the alternatively activated type 2 (M2).
It is likely that the hypertrophic, or activated, Type II cells account for the increased levels of surfactant found in the lungs after exposure to a variety of toxic agents.
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Overexpression of activated type-B ARR20 results in plants with small flowers, abnormal siliques and reduced fertility, whereas that of activated type-B ARR21 created seedlings in which cell proliferation is activated to form callus-like structures.
Correspondingly, CXCR3 and CCR5 chemokine receptors are expressed on activated type-1 T cells and associated with their local recruitment toward specific chemokines CXCL9, CXCL10, and CCL5 released by RSV-infected epithelial cells [ 4, 5].
Whereas cADPR generally activates type 2 ryanodine receptors (RyR2s), the NAADP-activated Ca2+ release mechanism is less clear.
TRAF3, STING, and TBK1 form a signaling complex that transmits upstream sensory responses to downstream effectors and then phosphorylates IRF3 to activate type I IFN production.
Angiotensin-II (Ang-II) enhances the modification of LDL and the expression of its lectin-like receptor (LOX-1) by activating type 1 (AT1) receptors.
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