The phrase "activated to decrease" is correct and usable in written English.
It can be used in contexts where a system, mechanism, or process is triggered or set in motion to reduce something, such as a quantity, level, or intensity.
Example: "The safety mechanism was activated to decrease the pressure in the system to prevent an explosion."
Alternatives: "triggered to reduce" or "set in motion to lower".
Maybe ICDH's TR activity could be activated to eliminate tellurite, but also decreased ICDH activity-mediated isocitrate accumulation could act as a signal to decrease the efficiency of the Krebs cycle to limit NADH generation and thus ROS production in the presence of the toxicant.
Similarly, ROS was reduced by 45% in cells overexpressing SIRT3 (lane 5) and was further increased by 10% when the SIRT3-expressing cells were treated with NAM (lane 6), supporting the role of SIRT3 in activating SOD2 to decrease cellular ROS.
Thus it seems that, at least on transcript level, a conserved positive feedback loop exists in eukaryotic cells, which might be activated to compensate for the decreased translational activity due to a loss of hypusine modification.
We next examined whether expression of genes involved in differentiation were activated to counter-balance the decreased expression of those associated with replication.
The IR phosphorylation reduces its ability to activate PI3K leading to decrease of the glucose transporters GLUT-4 translocation to the cellular membrane resulting in impairment of glucose uptake [ 31].
This sensory information can help guide the decision to shift from activating to calming questions and decrease the potential for dysregulation.
In addition, decorin has been shown to decrease activated microglia, macrophages, and other inflammatory cells accumulation, along with ventriculomegaly in hydrocephalic rats [ 21].
An intriguing property displayed by a number of signaling receptors is that of ligand-induced endocytic downregulation, where receptor-ligand complexes are internalized at rates greater than those of free receptors to decrease activated surface receptor levels [ 12- 14].
AMPK is activated in response to decreased intracellular ATP and then phosphorylates ULK1 and ULK2 (two Atg1 homologues) to activate both general macroautophagy and mitophagy [ 138].
25 SREBP-1 is most likely activated in response to decreased expression of Fgf21 and Insig2.
The hypoxic transcriptional response mediated by HIF-1 and HIF-2 is activated in response to decreased oxygen levels, increased ROS or growth factor stimulation.
