The phrase "activated through several" is correct and usable in written English.
It can be used when describing a process or mechanism that is initiated or triggered by multiple factors or methods.
Example: "The system can be activated through several different protocols, ensuring flexibility in its operation."
Alternatives: "triggered by multiple" or "initiated through various".
The NOX system can be activated through several signaling pathways, including mitogen-activated protein kinases (MAPKs), protein kinase C (PKC), and Ca2+ (Myhre et al. 2009); thus, it is likely that different PCBs may stimulate different aspects of this pathway, resulting in final assembly of an active enzyme.
As CCND1 is activated through several mechanisms, it is not a specific indicator of WNT activation.
PLSCR1 has been shown to be engaged when cells are activated through several plasma membrane receptors, including the epidermal growth factor receptor and the high-affinity IgE receptor [30].
A further level of complexity in regard to the role of Bid in the response to genotoxic stress lies in the fact that Bid can be activated through several distinct mechanisms after DNA damage.
NF-kB can be activated through several kinases including IkB kinases (IKKs).
Akt is involved in cell survival and proliferation in various tumor types and can be phosphorylated and activated through several signaling pathways, including MAPK and EGFR signaling.
On the other hand, FoxO3a is activated through phosphorylation by several stress kinases.
TGF- β1 and TGF- β3 can be activated through their interaction with several integrins, including alphavbeta5 [ 74, 76, 78, 87].
ATM is activated through one of the several mechanisms, the most significant of which is DNA DSBs, representing one of the most cytotoxic DNA lesions.
Mmp-9 is a gelatinase, which is synthesized as a proprotein, secreted, and activated through cleaving and proteolyzes several components of the extracellular matrix (Huntley, 2012).
The canonical pathway can also be activated through the signaling of several G protein coupled receptors, IL1- and toll-like receptors and tumor necrosis factor receptor type 1 (TNFR1), whereas the rest of the TNFR family usually activates the non-canonical NFκB pathway, leading to the formation of transcriptionally active NFKB2/RELB heterodimers (14).
