The phrase "activated through direct" is correct and usable in written English.
It can be used in contexts where you are describing a process or mechanism that is initiated or triggered directly by a specific action or input.
Example: "The system is activated through direct user input, ensuring immediate response to commands."
Alternatives: "triggered by direct" or "initiated via direct".
A recent study found MAP kinase p38α activated through direct binding by the adaptor protein transforming growth factor-β-activated protein kinase 1-binding protein 1 (TAB1) in the absence of upstream signals [62].
Further work has now revealed that Tip60 is activated through direct interaction between Tip60's chromodomain and histone H3 trimethylated on lysine 9 (H3K9me3).
NLRs prevail in the cytoplasm in a dormant form and are activated through direct or indirect binding of ligands to the LRR-receptor domain.
Whether PI3Kγ is activated through direct or indirect interactions with the EpoR remains to be determined.
COP1 is a negative regulator controlling the degradation of transcription factors activated through direct interaction with photoreceptors [ 47, 69, 70].
In this case, cell cycle is activated through direct amplification of cyclins and TP53 inactivating mutations unable cells to repress proliferation.
Alternatively, JNK may be activated through other direct or indirect integrin signalling pathways.
In contrast to the tumor suppressive functions of miR-200 and miR-34, the miR-9 family appears to be tumor activating through a direct interaction with the CDH1 promoter which subsequently initiates EMT [49].
In parallel, the energy sensor AMPK (5′ adenosine monophosphate-activated protein kinase), which is abundant in cardiomyocytes, can activate autophagy through direct activation of ULK1 or by inhibiting mTORC1 in mammalian cells.
Similar to resveratrol, controversy exists regarding whether SRT1720 activates SIRT1 through direct interaction, or acts indirectly via activation of AMPK through alterations in cellular energy status.
As ATP activates KpBest through direct interaction, we speculated that the same mechanism is at play for hBest1.
