Your English writing platform
Discover LudwigSimilar(60)
Similarly, Gilbert et al. fused dCas9 to the activation domains of either VP64 or p65 to activate targeted genes (Gilbert et al. 2013).
ESR2 only had activated targets, whereas AR and NR5A1 had as many activated as repressed targets.
The present analysis therefore fully confirms and extends the information about known activated targets.
Instead of using a p-value cutoff for co-expression, we used the number of ARACNe predicted activated targets as a cutoff.
Orange indicates activated targets (between 1.5-fold and twofold).
Interestingly, these neural markers show as much high-density T-box TF binding as some activated target genes mentioned above.
STATs are cytosolic proteins that, upon activation, translocate in to the nucleus to activate target genes.
A simple model postulates that a morphogen activates target genes by directly activating a latent transcriptional activator (Driever et al., 1989).
Thus, Foxo targets impose a translational program by activation of genes that repress general translation while simultaneously activating targets that are immune to this translational control.
New developments in DBS are focusing on enabling directional stimulation capabilities that may possibly activate targets with greater specificity.
Early studies suggested that specificity is dictated by sets of differentially induced transcription factors that synergistically activate target genes containing their binding sites.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com