Sentence examples for activated smooth from inspiring English sources

We previously showed that lithocholic acid (LC) and other cholane derivatives activated smooth muscle BK channels and, thus, caused endothelium-independent cerebral artery dilation.

Our results show upregulation of TGF-β signalling pathways and vessel wall fibrosis in the systemic arterial circulation, altered vasoreactivity, and a TGF-β activated smooth muscle cell phenotype with additional perturbation of endothelin axis signaling.

In the development of atherosclerosis, activated smooth muscle cells in the medial layer of arteries migrate to the atherosclerotic fatty streaks in the intimal layer and produce an extensive extracellular matrix.

Histology of lungs 14 days after bleomycin challenge revealed extended areas of fibrotic changes in wild-type animals, characterized by accumulation of activated, smooth muscle antigen-positive fibroblasts and deposition of crosslinked collagen fibers.

Because also of the ability to activate smooth muscle PPARγ to induce relaxation, Wy14643 offers additional protection against vascular dysfunction of spontaneous hypertension.

When the liver is injured by infection or toxins like alcohol, it repairs the damage by activating smooth, muscular liver cells.

This study [25] also shows that miR-145 is activating one of its direct targets, the myocardin (Myocd), which is a transcription factor well known to activate smooth muscle gene expression by interacting with SRF [26].

Generation of sphingolipid metabolites such as ceramide, sphingosine, and sphingosine-1-phosphate can activate smooth muscle cell proliferation, endothelial cell differentiation, apoptosis and cell death, migration, vasoconstriction, and dilation.

For example, plasma prothrombin and plasminogen are convected and activated on smooth muscle cell in aneurysms of the ascending aorta, participating to the degradation of the arterial wall.

This possibility is consistent with the leiomyosarcoma formation seen when PI3K/mTOR signaling is inappropriately activated in smooth muscle cells by deletion of the negative regulator, PTEN [ 41].

The adverse role of elevated HMGB1 levels is supported by observations at the molecular level showing that fatty streaks and fibrofatty lesions contain more macrophages with cytoplasmic and nucleic HMGB1 compared with normal intima [ 6], and that HMGB1 is also expressed by activated vascular smooth muscle cells in more advanced atherosclerotic lesions [ 7].