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As a result, PDCD4 downregulation activated proliferation and migration and suppressed apoptosis of SW480 cells, whereas PDCD4 overexpression had the opposite effect on cell proliferation, migration and apoptosis (Fig. S1D I).
All of the growth factors that activated proliferation and fibronectin matrix accumulation stimulated the transformation of the mesenchymal cells into myofibroblasts that displayed the marker α-smooth muscle actin.
In keeping with the known role of Myf5 in myoblast accumulation during mouse muscle regeneration DUX4c over-expression activated proliferation of human primary myoblasts and inhibited their differentiation.
This has been seen in zebrafish, where a heart repairing unit consisting of GATA4 expressing cardiomyocytes has activated proliferation [ 4].
BM-DCs transduced with IiOVA-GFP or IiOVA-p5-GFP activated profiferatiOVA-specificeCD4ic CD4 and CD8 T cells purified from transgenic OT-II and OT-I mouse strains, respectively (results not shown).
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In BL, inactivating mutations of ID3 and activating mutations of TCF3 result in enhanced E2A function, which activates proliferation through induced cyclin D3 expression and survival through activation of PI3K signaling [136].
ESCRT-deficient cells also activate Notch signalling, which triggers the release of a cytokine thus activating proliferation in adjacent, normal cells [16] [19].
Moreover, we showed that the DCs transfected with scFv were capable of efficiently activating proliferation of total lymph node cells and inducing a decrease in lung infection.
cAMP accelerates the proliferation of cyst-derived cells in ADPKD, but does not activate proliferation of normal renal cells.
A reciprocal relationship of proliferation and differentiation is recognized by a decrease in genes that activate proliferation as cells differentiate.
These observations suggest that ductal cells with pancreatic progenitor properties activate proliferation prior to differentiation into beta cells during regeneration.
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