Due to such long-range action, the acoustic pulses from the ions of C+, Ar+ and Xe+ bombarding the DLC target can activate migration of defects at depths up to 50 nm and considerably reduce the activation energy of kinetic process at depths up to 300 nm.
Moreover, macrophages produce EGF, which activates migration of tumor cells [ 46].
Those cytokines will activate migration of lymphocyte cells into the ocular surface with more secretion of inflammatory cytokines, chemokines, metalloproteinases, and proangiogenic molecules that will facilitate the infiltration of pathogenic immune cells that give rise to the clinical picture [ 5].
8, 10 In addition, research has suggested that CXCR4 may be involved in the promotion of metastatic potential in multiple tumor types, by activating migration and homing of tumors.
Because activating migration and invasion is one of the hallmarks of cancer (Hanahan and Weinberg, 2000, 2011) and key to metastasis (Nguyen et al., 2009), the transfer of biomolecules, including mRNAs involved in migration, may affect not only the migratory behavior but also the metastatic potential of tumor cells.
Therefore, LPA directly activates the migration of breast cancer cells, which is a critical step for tumor metastasis.
CXCL12 was reported to activate the migration of human melanoma and breast cancer cells that express CXCR4, ROBO1 and ROBO2, while SLIT2-ROBO interaction was demonstrated to inhibit chemotaxis, chemoinvasion and adhesion of breast cancer cells [ 20].
Interestingly, cytokinesis failed in 25% of oocytes expressing Cdc20R132A, possibly because the APC/C had been activated prior to migration of the spindle to the cortex.
Interferon-γ-inducible protein-10 (IP-10), also referred to as CXCL10, is a chemokine that plays an important role in the integrin activation and migration of cells, including activated T cells, monocytes, eosinophils, natural killer, epithelial and endothelial cells.
