Sentence examples for activated largely through from inspiring English sources

Giving that the checkpoint is activated largely through protein phosphorylation and kinase cascades, the emerging role of protein phosphatases in checkpoint recovery is not surprising [ 27].

YAP and TAZ are transcription co-activators activating gene expression largely through interaction with TEAD (homolog of Drosophila Scalloped, Sd) family and other transcription factors.

Second, the areas activated were largely non-overlapping, as is clear from Figure 1.

The mechanisms by which dimers of cREL are activated remain largely unknown.

Our findings demonstrate that putrescine activates AdoMetDC primarily through positioning of active site residues and electrostatic effects relayed to the active site largely through hydrogen bonding.

While there is some understanding of the activity pathway of these individual signaling molecules, detailed knowledge of transcriptional controls activated through these signaling pathways is largely unknown.

Enhancers are regulatory DNA elements that can activate transcription largely independent of their location or orientation.

The metabolic regulation is largely controlled by 5′-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1.

Regardless of the mechanism, we confirmed that Fum-PD activated AMPK in vitro and in vivo largely through a NO-dependent pathway, as l-NAME reversed the observed fumagillin-induced AMPK activation.

Importantly, this effect was largely limited to those genes identified as activated by Otx2 through our siRNA analysis.

CYP epoxygenase-derived eicosanoids are vasodilatory, largely through their ability to activate eNOS and NO release[ 16].