The phrase "activated is direct" is not correct and does not convey a clear meaning in written English.
It may be intended to describe a state of activation that is straightforward or unambiguous, but the phrasing is unclear.
Example: "When the system is activated, it is direct in its response to user commands."
Alternatives: "activated is straightforward" or "activated is clear".
Currently, the majority of our routes with sales activated are direct booking.
These data add further evidence to our conclusion that MCH neurons regulate the activity of DA neurons in the VTA but do not address whether the ability of MCH neurons to activate these neurons is direct or indirect (Dr Blackshaw correctly points out that this could possibly be mediated via orexin neurons or another neural population).
None of the other members of PRC1/PRC2 complexes we examined, including enzymes responsible for deposition of PcG-associated histone marks (Ring1a/1b, Ezh1/2), or members of the KAT and TrxG activating complexes, were direct targets of SCL (Fig. 6f, g, Supplementary Fig. 7), highlighting the unique relationship between SCL and RYBP/PCGF5.
Our results show that lateral aspects of the rostral PFC are preferentially activated when attention is directed to internal representations, whereas anterior medial aspects are activated when attention is directed to sensory events.
These results suggest that STACs that fail to activate E230 mutants are direct activators of SIRT1.
First, Bach1 possesses an exportin1/Crm1-dependent nuclear export signal (NES) whose activity is activated by direct heme binding (Fig. 1A).
Thus, misfolded proteins likely are direct ligands that activate Ire1, while Kar2 fine-tunes the signaling (Pincus et al., 2010; Gardner and Walter, 2011).
One possibility to 'unify' the original models may be in a model where Bax is physiologically activated by direct activation (Bax is inactive until receiving a signal through BH3-only proteins) whereas Bak is activated indirectly (auto-activates when the inhibition by Bcl-2-like proteins is relieved).
In summary, we provide evidence supporting our hypothesis that the mechanism by which E2 activates AMPK is through direct interaction of ERα and ERβ with the α-subunit of AMPK.
Before the actual direct link communication between STAs is activated, the direct link connection should be established based on the connectivity information.
