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In order to be fully active, CPT-11 needs to be activated into the active compound SN-38 (7-ethyl-10-hydroxycamptothecin) by carboxylesterase (CE) enzymes (Tsuji et al, 1991; Satoh et al, 1994).
Upon activation of the coagulation cascade, prothrombin is activated into thrombin.
Once LCFA cross the membrane, most are activated into an LC-acyl-CoA (LCACoA) primarily via ACSL1 (activation shown by small red dots).
In an open surgical site, these products can be activated into a fibrin gel that offers additional local antihemorrhagic and sealing properties.
This work aims exploring the high performance porous separators that can be activated into gel electrolyte membranes for lithium ion batteries.
Once stimulated by certain mitogens, these cells would be activated into the cell cycle (by progressing from G0 into G1 and subsequently into S, G2, and M) and promoted to proliferate and differentiate.
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It was evident that being geographically close to Dehradun was important for potential members to activate into the network.
Renal cortical fibroblasts maintain a quiescent state in normal kidneys, but in response to injury they proliferate and activate into myofibroblasts.
Upon injury or chronic insult, these cells activate into wound-healing cells, called myofibroblasts, and repair the damaged tissue through enzyme and protein secretion.
To accomplish these tasks, fibroblasts proliferate, migrate to the wound site, and activate into myofibroblasts, forming highly-organized cytoskeletons containing α-smooth muscle actin (αSMA) stress fibers to enable contraction and wound closure (Fig. 1B).
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