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By applying a novel statistical framework for analyzing gene expression data generated from a single tumor, VIPER then determines the activity of all cancer-relevant proteins, identifying those that are abnormally activated in a specific tumor.
This suggests that the locus is tightly regulated and mostly repressed but can be activated in a specific spatio-temporal manner.
The present results demonstrate that the ICU muscle wasting represents unique muscle wasting condition where multiple signalling pathways are activated in a specific temporal pattern.
It seems that protective muscles are selectively activated in a specific pattern in order to protect the radial nerve from mechanical tension by shortening its pathway, suggesting integration of muscle and neural mechanisms.
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However, in the presence of the aptamer's target protein human α-thrombin, the inhibitory effect of the DNA aptamer is competitively neutralized and the ribozyme is activated in a highly specific fashion.
This further supports the notion that TFBSs in cluster 2 become activated in a lineage specific way following embryonic stem cell differentiation.
Western blots provide an indication of the overall level of MAPK signalling; however, the MAPK signalling pathway is activated in a highly specific temporal and spatial manner during development.
These nonclassical signaling pathways are activated in a stimulus-specific and cell-type-specific manner downstream of IFNAR.
Here, we summarise recent progress in understanding the structural mechanism of how the tug-of-war between intramolecular and intermolecular interactions allows these protein 'nanomachines' to become activated in a site-specific manner.
As a control, we can show that MTH-Cg2-19 micancan be activated in a forebrain-specific manner in crosses with tTACaMK mice (Fig. S3B, also see Fig. S2B).
We found Cyp2b10, a known CAR target, to be concomitantly hypomethylated and activated in a tissue-specific manner following PB treatment and revealed a PB-mediated epigenetic switch at the promoter of this gene.
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CEO of Professional Science Editing for Scientists @ prosciediting.com