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Once activated, HER receptors initiate the recruitment of intermediate signaling proteins, which subsequently activate downstream signal cascades that trigger the cellular responses [ 2].
VeraTag™ lysate assays can be used as a tool for understanding the mechanism of action of targeted HER-family inhibitors in the preclinical setting, while VeraTag™ FFPE assays of activated HER receptors combined with total HER2 measurements (HERmark®) in tumor samples may provide a more accurate prediction of clinical response to both HER1 and HER2 targeted therapies.
I think that's when she activated her bomb.
The mold had activated her allergies, she said, and she had lost weight since the storm.
As a cultural icon, the pressures of undertaking another memoir activated her most primal fear: that she would disappoint people.
Senator Hillary Rodham Clinton activated her entire campaign apparatus to portray Mr. Obama's remarks as reflective of an elitist view of faith and community.
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MVA-BN®-HER2-induced anti-tumor activity was characterized by an increased infiltration of lungs with highly activated, HER-2-specific, CD8+CD11c+ T cells accompanied by a decrease in the frequency of Treg cells in the lung, resulting in a significantly increased ratio of effector T cells to Treg cells.
These were used for measuring IFN-γ release from the activated HER-2 specific CTLs and control lymphocytes in the co-culture/cytotoxicity experiments as described above.
All three compounds activated hER-αand hER-β in vitro.
Similarly to the protection observed in rats by a pregnancy level of estradiol, activated Her-2/ neu mice are also rendered refractory to mammary cancer development by short-term hormone treatments.
Virgin activated Her-2/ neu transgenic mice have a 100% incidence of mammary cancer and a high multiplicity of mammary cancers [ 14, 15].
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