Interestingly, L-type calcium channels can be activated by rather weak depolarization events (−55mV to positive)18 and cancer cells have been reported to have depolarized membrane potential compared with their healthy counterparts46.
It is possible, though not proven, that striatal neurons may be activated by the weak US and directly or indirectly involved in the consolidation or retrieval of the long-term fear memory.
The synchronization of weak continuous tremor and eruptions suggests that hydrothermal activity is also activated by magma transport during eruption periods.
Chromatin structure in the β-globin locus in uninduced MEL cells, such as hypoacetylation of histones and weak association of RNA polymerase II and transcription activators, is strongly activated by the chemical induction [ 3, 25– 27].
Bcl-w is up-regulated also through pathways besides the Akt one: Tran et al. demonstrated that Bcl-w can be up-regulated via the NFkB pathway activated by TWEAK (tumor necrosis factor-like weak inducer of apoptosis) through stimulation of its receptor, Fn14; moreover, the TWEAK-Fn14 pathway can induce survival of glioma cells, at least in part by up-regulating the quantity of Bcl-w protein [40].
Conversion of early long-term potentiation (E-LTP, an in vitro correlate of short-term memory) into L-LTP (a physiological correlate of long-term memory) at synapses activated by a strong stimulation after a weak one suggested that synapses activated during behavioral memory acquisition might be tagged for a protein-synthesis-dependent long-term consolidation.
Although VEGFR1 has a higher affinity for VEGF-A than does VEGFR2, in endothelial cells VEGFR1 exhibits only weak tyrosine phosphorylation when activated by VEGF-A induced dimerization.
BCL10 encodes a protein that appears to both activate and be activated by NFκB and overexpression of BCL10 causes weak apoptosis mediated via an amino terminal caspase recruitment domain (CARD) [ 18, 19].
"It just tells us that even though these are weak signals, the human brain is activated by them".
The player must learn to maximise the potential of their various weapons and tools, switched between using both the D-pad and a wheel activated by the right bumper, and see what each machine is weak against, in order to best bring it down – ideally without alerting others to come and gang up on you.
