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We hypothesized that these B-cells could have been activated by unique antigens derived from the tumors.
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The prodrug capecitabine is activated by a unique mechanism that exploits the high activity of thymidine phosphorylase in malignant tissue that generates 5-FU preferentially in tumor tissue [ 7].
These receptors, referred to as PARs (protease-activated receptors), are typical seven-transmembrane, G protein-linked receptors that are activated by a unique mechanism.
Unlike the latter group of receptors, which signal through standard receptor/ligand interactions, PARs are activated by a unique proteolytic cleavage within the first extracellular loop or by synthetic peptidomimetics corresponding to the new N termini generated after receptor cleavage.
The catalytic core of ErbB kinases have functionally diverged from other RTKs in that they are activated by a unique allosteric mechanism that involves specific interactions between the kinase core and the flanking Juxtamembrane (JM) and COOH-terminal tail (C-terminal tail).
PARs are transmembrane G-protein-coupled receptors (GPCRs) that are activated by a unique proteolytic mechanism.
PHY906 together with CPT-11 triggers unique changes not activated by each one alone suggesting that the combination creates a unique tissue-specific response.
These voices are rarely if ever heard in the mainstream press of the U.S. And, we witnessed what impressed Jimmy Carter so much – a uniform, electronic voting system which guarantees one person, one vote through a biometric authentication tool which only allows the system to be activated by a voter's unique fingerprint and ID number.
The cell death cascade activated by MTX is not unique to this toxin.
This subgroup of genes may be activated by an AhR-independent mechanism unique to PeCDF and PCB126.
Although the sensor proteins are all activated after dissociation from the intraluminal chaperone Ig-binding protein (BiP), the signaling pathways activated by each of these sensors are unique.
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