FAK is activated by several stimuli, including activation of integrin and growth factor receptors (Sieg et al, 2000; Benlimame et al, 2005).
Moreover, it is thought to have a central role in the MMP activation cascade, both activating and being activated by several other MMPs (MMP-14, -2 or -3).
Moreover, it is thought to play a central role in the MMP activation cascade, both activating and being activated by several other MMPs (MMP-14, 2, or 3).
MMP-13 also plays a central role in the MMP activation cascade, both activating and being activated by several MMPs [ 8].
Thus, PTEN antagonizes the activity of phosphatidylinositide-3-kinase (PI3K) that is activated by several receptor tyrosine kinases (RTKs) upon binding of ligands, like insulin, insulin-like growth factor-1 and epidermal growth factor [16], [17], [18].
PPARγ is activated by several natural and synthetic ligands, and its activation elicits cell differentiation and induces cell cycle arrest and apoptosis (3, 4).
Generation of ROS by phagocytic cells, mostly mediated by Nox2, is activated by several stimuli through receptor-mediated protein kinase activation.
Since phosphorylated Net1 is inactive [36], it is likely that activation of Net1 involves dephosphorylation by a phosphatase, which itself could be activated by several different kinases stimulated by IR.
The arm was attached to a wall and activated by several motors, which, in turn, were controlled by a computer.
STAT3 is present in the cytoplasm and are activated by several factors particularly IL-6.
Ligand to receptor binding is not unique and one receptor can be activated by several FGFs.
