Sentence examples for activated by sequential from inspiring English sources

Promoters that contain multiple κB sites, both A/T- and G/C-centric, such as IP-10, MCP-1 and A20, would persistently be activated by sequential engagement of different NF-κB dimers/complexes, such as early activation by RelA dimers and late activation by the p52 Bcl3 complex.

Complement activation occurs through three convergent pathways, in which the C components are usually activated by sequential proteolytic cleavages and/or by binding to previously activated components.

In mature adipocytes, glucose uptake is carried out by GLUT4 which is driven by insulin signaling transduction that is activated by sequential posphorylation of insulin signaling proteins, including IR, IRS1, PI3K and Akt2.

PIP3 binds to Akt, then translocates to the plasma membrane where Akt is activated by sequential phosphorylation at T308 and S473 residues.

The enzyme is activated by sequential binding of product molecules with dissociation constant K P = (k P − / k P + ) for each binding step.

The molecule is activated by thrombin following sequential cleavages at Arg, Arg, and Arg to generate the active cofactor (factor Va) composed of a heavy chain [ Mr = 105000 (A1-A2 domains)] and a light chain [ Mr = 74000 (A3-C1-C2 domains)].

Briefly, Akt is a serine/threonine kinase involved in cell proliferation, apoptosis, and glucose metabolism and is differentially activated by growth factors and oxidative stress by sequential phosphorylation of Ser473 by mTORC2 and Thr308 by PDK1.

The inactive form of STAT3 in the cytoplasm of non-stimulated cells is activated by cytokines, growth factors and oncogenic proteins through sequential phosphorylation of tyrosine 705 and serine 727 [ 20].

The extracellular signal-regulated kinase mitogen-activated protein kinase mitogen-activatedy is activated by mitogenic stimuli mediated by receproteinpe tyrosine kinases and G-protERK MAPKled recepathwayleadisg to sequentiactivatedorylation of RAS, RAF, MEK and ERK1/2.

Respiration was activated by adding 5 mM pyruvate and 5 mM malate (final concentrations) followed by sequential additions of 50 nmol ADP.

Hox genes are differentially activated by retinoic acid in a concentration-dependent manner and in a sequential order that is collinear with their 3' to 5' arrangement in the cluster [44].