The phrase "activated by multiple" is correct and usable in written English.
It can be used in contexts where something is triggered or initiated by several factors or elements.
Example: "The system is activated by multiple sensors that detect changes in the environment."
Alternatives: "triggered by several" or "initiated by multiple".
The receptor TK activity of EGFR can be activated by multiple ligands, such as EGF.
Dynamin activity has been shown to be activated by multiple phosphoinositides, including PI(3 P, PI(4 P and PI 4,5 P2, in vitro (Yarar et al, 2008).
PI3-K itself is activated by multiple mechanisms, including the activation of growth factor receptor tyrosine kinases [ 5, 6] and G protein-coupled receptors [ 7, 8], integrin-mediated cell adhesion [ 7, 8], and the actions of oncogene products such as Ras [ 9, 10] and hormones such as estrogen [ 11- 13].
Similarly, the transcriptional activity of the NF-κB complex is activated by multiple stresses, including oxidative, shear, ER, and hypoxic stress [ 47- 51], and is predicted to have increased activity in three of the four data sets: hypoxia, OxPAPC, and hyperoxia.
Stress-activated protein kinase/c-Jun N-terminal kinase is activated by multiple forms of stress including UV, radiation, inflammatory cytokines, and has been implicated as a mediator of stress-induced apoptosis (Davis, 2000).
The 15 signaling effectors employed in this study were specifically chosen as they are critical signaling nodes activated by multiple pathways and are likely candidates as indicators of activation in multiple cell populations.
Although the level of pERK, an upstream activator of pCREB, was reduced in the present study, CREB can be activated by multiple signal pathways including PI3K/Akt and Ca/CaM/CaMK IV signalling [ 37, 38].
The 15 signaling effectors employed in this study were specifically chosen as they are critical signaling nodes activated by multiple pathways and as such are likely candidates as indicators of activation in multiple cell populations.
AMPK itself is activated by multiple mechanisms including phosphorylation by the tumor suppressor LKB1/STK11 kinase in response to increased AMP or ADP levels in the cell11, 12.
When EphB4 is activated by ephrinB2, multiple tyrosine sites are phosphorylated and the kinase domains activated, although soluble forms of either ephrinA or ephrinB cannot activate their receptors (Davis et al, 1994; Katoh and Pasquale, 1999).
Akt is activated by phosphorylation at multiple sites through phosphatidylinositol-3-kinase signaling, and binding of carboxyl-terminal modulator protein (CTMP) can prohibit this activation20.
