Sentence examples for activated by methylation from inspiring English sources

FoxO proteins are also activated by methylation.

SAM-Mtases may also act on cucurbitadienol by catalyzing methylation, as it is known that many compounds with anti-microorganism functions have cucurbitadienol backbones activated by methylation [ 23].

Although involvement of epigenetics in lung cancer has not been well investigated, WNT signaling could be activated by methylation of APC, 58 SFRP2, SFRP5, SFRP5, and DKK3 60 in a subset of lung cancer.

If, however, mRNA cap methylation could be regulated post-transcriptionally, then unmethylated mRNAs will represent a dormant pool that could potentially be activated by cap methylation.

As FoxO3a is activated by arginine methylation with PRMT1, we determined the role of PRMT1 on Bim expression upon A β1-42 exposure by using an inhibitor of PRMT1, and found that its inhibition blocks the Bim induction by A β1-42.

The epigenomic features of the LoDs could account for the finding that CTA genes can be activated by inhibition of DNA methylation but not by a reduction in H3K9 dimethylation, and suggest that DNA methylation is the key epigenetic mechanism involved with the regulation of LoD CTA genes.

Although of its predominant down expression in many cancer cell lines, the mixed levels of miR-34a in different liver cancer cell lines reported by different investigators may reflect the opposing mechanisms that affect its expression (activated by P53 and inactivated by methylation and many other factors) and contribute to enhancement or decrease of its tumor suppressor role in fighting cancer.

However, secondary metabolism gene clusters can be directly activated by manipulation of histone methylation [ 24] or histone deacetylation related genes [ 25] as well as induction of a cluster's Zn2Cys6 transcription factor [ 26].

The detection of two RNA FISH signals in treated neonatal fibroblasts, therefore, indicates that the normally silent maternal allele has been activated by the loss of cytosine methylation.

Typically, intracellular signalling molecules are activated by modification, e.g. phosphorylation or methylation, and interact in complicated biochemical reaction networks.

However, bisulfite sequencing showed that genes repressed by MeCP2 presented a higher degree of methylation than genes activated by MeCP2.