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For instance, Pozzi et al. demonstrated that retinoic acid (RA) induced epigenetic activation of CYP26A1 required the activity of RAR β2, which was further activated by functional RAR α in response to RA. Future researches investigating the coordinated network involving chains of signaling upstream of the epigenetic codes are essential to unveil the mystery of gene regulation.
To validate the model, the ankle dorsiflexion activated by functional electrical stimulation (FES) is subjected to an inverse dynamic analysis (IDA).
In addition, there is reduced expression of pro-retinal genes normally activated by functional Rx3.
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Aziz-Zadeh of the University of Southern California will track what parts of the brain are activated by metaphor using functional Magnetic Resonance Imaging.
STAT proteins, once activated by phosphorylation, form functional homo- or hetero-dimeric complexes that migrate to the nucleus and target specific promoter elements to initiate transcriptional activation.
And so in ESCs, where activators maintain expression of pluripotency genes, differentiation genes could simply be off (by default, as it were) until activated by some activators that are rendered functional by virtue of gain (or loss) of a signal.
These results indicated that when VirR or VirRD57N was present in the cell at higher concentrations, the response regulator no longer needed to be activated by phosphorylation to be functional.
OX2R in mammals retained its ligand specificity for orexin A and B descended along the vertebrate lineage; while OX1R is specifically activated by orexin A. The functional diversifications of orexin receptors and SCTRs in mammals were fine-tuned to be activated by their own endogenous peptides, resulting in the loss of the reciprocal activation observed in non-mammalian vertebrates.
Mouse and human PPARα were both activated by TRI exposure, but the functional consequences of activation differed substantially between mouse and human PPARα, with significantly higher PT and PH mRNA and protein induction by TRI exposure in m PPARα than in h PPARα mice.
This temporo-occipital area appears to constitute a major component of the functional network activated by this spatial attention task.
Furthermore, we noted that odorant receptors that are activated by odorants of the same functional class, but expressed in different sensilla (Hallem et al. 2004), may interact with common OBPs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com