Exact(14)
JNK was activated as early as 1 h after MG treatment and this activation was maintained for 2 h.
We first confirmed that P-JUN is activated as early as 6 hpa (Fig. 2c), and the pharmacological compound SP600125 inhibited JNK activity in fish (Fig. 2d).
The mechanisms that are made responsible for EBI are believed to be activated as early as the aneurysm rupture.
We found that in two different biological replicate experiments Pitx2 was activated as early as 2 hours after Alk4* de-repression (removal of SB).
This transgenic mouse produced a bicistronic mRNA coding for both cytokeratin 12 (KRT12) and reverse tetracycline transcription activator (rtTA) under the control of the corneal epithelium-specific Krt12 promoter, which is activated as early as embryonic day 14.5.
As shown in Figure 6a, P38 was activated as early as 15 min after Khz-cp treatment.
Similar(46)
This suggests that the UPR subclass activated as an early response to stress is transformed into a different subclass as the stress is either resolved (i.e. adaptive) or persists (i.e. stressed or terminal).
B cells were activated as described earlier for 7 days.
JNK was strongly activated by HGF, reaching maximal activation as early as 5 10 minutes after HGF addition (Fig. 3C).
These time points were selected because they represent three distinct states of AP-1 activation: AP-1 activated as ppc-Fos:ppc-Jun (early); AP-1 activated as equal parts ppc-Fos:ppc-Jun and ppc-Jun:ppc-Jun (intermediate); and AP-1 activated as ppc-Jun:ppc-Jun (late).
AP-1 is predicted to be activated as ppc-Fos:ppc-Jun at early times, when global sensitivity analysis finds AP-1 to be most sensitive to the development and maintenace of ppc-Fos:ppc-Jun, before shifting to be activated as ppc-Jun:ppc-Jun at later times, when the most sensitive reactions are related to the development and maintenance of ppc-Jun:ppc-Jun.
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