GraB can therefore activate two independent pathways to caspase activation that bypass anti-apoptotic proteins commonly elevated in cancer.
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases.
By acting as a mitogen-activated protein (MAP) kinase kinase kinase (MAPKKK) ASK1 can activate two distinct sets of MAPKK.
Moreover, in the mouse osteoblastic cell line MC3T3-E1, TGF-β washownwn by genetic screening in yeast to activate two novel proteins, TAK1-binding protein (TAB1) and TGF-β-activated kinase (TAK1) [ 93, 94].
One of SIRT1's functions is to deacetylate and activate two proteins called forkhead box protein O1 (FOXO1) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α), a key regulator of energy metabolism.
Neurotrophins activate two types of cell surface receptors, the Trk receptor tyrosine kinases and the shared p75 neurotrophin receptor.
NPY appeared to activate two distinct signalling cascades that liberate calcium from thapsigargin- and ryanodine-insensitive compartments.
Disulfide cleavage in 8 would generate two thiol groups that could serve as probes to activate two mitomycin rings.
As they do so, they activate two critical arms of host defense, the rapid innate immune response and an adaptive immune response.
We have about 20 projects in a feasibility study stage where we'll probably activate two or three a year, so we are always looking to set up new locations.
Suddenly faced with what he admitted was "a sense of urgency" approaching Sunday's game against the Baltimore Ravens, Jets Coach Bill Parcells will activate two rookies to try to jump-start his special teams.
