Sentence examples for activate trail from inspiring English sources

This work suggests that tumors, which have evolved TRAIL resistance mechanisms [16] such as Six1 overexpression will not only respond less well to drugs such as Apo2L/TRAIL, lexatumumab, mapatumumab, ApoMab, AMG 655 etc. [2] that directly activate TRAIL receptors, but may also respond less well in vivo to conventional cytotoxic chemotherapy.

It is not known whether the removal of TRAIL repression following the detachment of AML1/ETO from TRAIL promoter is due to the fact that hypoxia enable other hypoxia-induced factors to bind the promoter and activate TRAIL transcription.

Expression of NFATc1 activated TRAIL promoter activity and increased TRAIL mRNA and protein expression.

The V108E mutant was recruited only to activated TRAIL receptors.

However, once procaspase-8 has been activated, TRAIL-induced apoptotic signalling may be propagated either by a mitochondrial-independent or a mitochondrial-dependent pathway [ 14].

The death receptors TRAIL-R1 (DR4), TRAIL-R2 (DR5) and CD95 (Fas) are specialised members of the TNF receptor superfamily and are key mediators of apoptosis triggered by ligands expressed by cells of the immune system, namely TRAIL (TNF-related apoptosis-inducing ligand), which activates TRAIL-R1 and TRAIL-R2, and CD95L (FasL), which activates CD95.

By binding to TRAIL-R2, TRAIL activates the cleavage of caspase-8 and -3, which in turn cleaves and inactivates PPAR γ.

1, 2 Death receptor 5 (DR5; TRAIL-R2) and death receptor 4 (DR4; TRAIL-R1) are members of the TNF family that are activated by TRAIL.

In conclusion, the senescence secretome may sensitize both premalignant cells and certain TRAIL-resistant tumors upon chemotherapy, thus providing a rationale for the co-administration of TRAIL or TRAIL pathway-activating therapeutics.

Lexatumumab (HGS-ETR2) is a fully humanized agonistic monoclonal antibody that specifically activates the TRAIL-R2 and has never been tested in thyroid cancer in any capacity.

To examine whether the JNK pathway was activated during TRAIL-induced colon cancer cell death, phosphorylation of JNK and its target, c-Jun were assessed by western blot analysis following treatment with rhTRAIL.