Thus, the profile " u s D u s H " (read "up, then stable diploids, up, then stable haploids") regroups genes activated at transition to the early 14 th mitotic cycle in diploids (transition X D 14 E between time points D13 and D14E), but one cycle later in haploids (transition X H 15 E between time points H14 and H15E).
As our identifications indicate that AF4 interacts with Pol II and the Mediator complex, we may speculate that AF4 binding induces a structural change in Mediator thereby activating stalled Pol II to transition to a positively elongating state and enabling effective transcription to take place.
EDCs and EPCs respond to fibroblast growth factors (FGFs) in both embryogenesis and regeneration processes and undergo a number of cellular modifications11 that is required to activate the transition from epithelial to mesenchymal cells, such as cytoskeletal re-arrangement and expression of hyaluronan-mediated motility receptor, neccessaries to move in the damage site 12,13.
Although little is known about the signal or the pathway(s) it activates to induce the transition, several lines of evidence indicate that it is mediated by steroid hormone signaling.
In the course of the present studies, we have shown that exposure to transition metals activates recombinant overexpressed TFEB.
The male germline transcriptome changes dramatically during the mitosis-to-meiosis transition to activate late spermatogenesis genes and to transiently suppress genes commonly expressed in somatic lineages and spermatogenesis progenitor cells, termed somatic/progenitor genes.
Before discussing the island/wire stability, it is interesting to estimate the Si content which is needed to activate the shape transition.
Moreover, the TFs that regulate translocation from the nasopharynx to the lungs clustered with those activated during transition from the blood to brain for both strains, albeit at a lower level.
A mathematical model could provide the means to systematically identify the set of nodes which need to be inhibited rather than activated to achieve desired cell type transition.
Wu, C. F. et al. Transforming growth factor β-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis.
One of the earliest genes activated in the transition to flowering, SOC1, was found to show a five-fold increase in expression during stages M1 M4 and a three-fold increase in expression during M3 M4, while FD is highly expressed in SAMs before floral induction and undergoes a further increase in expression at later stages [ 14].
