Sentence examples for activate this alternative from inspiring English sources

Therefore, cancer cells, by using a less efficient PK isoform, will activate this alternative pathway allowing the dissociation between ATP production and the anabolic processes that are required for fast cancer cell division.

Part of the role of complement relates to recognizing and clearing damaged cells; given the organ damage occurring in TTP secondary to microvascular thrombosis, this alone may be sufficient to activate the alternative complement pathway.

MSU crystals also activate the alternative pathway in vitro [ 46] and, in this process, direct cleavage of C5 to C5a and C5b is triggered by the formation of a stable C5 convertase on the MSU crystal surface [ 47].

To verify if these strains activate the alternative pathway, C3b deposition was analyzed in serum treated with EGTA to chelate Ca2+.

It may indirectly activate the alternative pathway as a consequence of activating the classic pathway [ 41, 44, 45].

Stimuli that activate the alternative pathway include Lymphotoxin (LT β R, B-cell activating factor receptor (BAFFR), receptor activator of NF-κB (RANK), and CD40 [ 4, 10, 11].

It has been speculated that accumulation of ICs involving GPI may activate the alternative complement pathway to cause inflammatory arthritis [ 16].

Of note, monoclonal λ light chains from a patient with DDD have been reported to activate the alternative pathway directly through an interaction with CFH.

Immune complexes with the IgG2 subtype activate the alternative complement cascade pathway and are important in defence against encapsulated bacteria [ 26, 27].

Recent studies also showed that COMP has the potential to activate the alternative complement pathway and can inhibit the classical and lectin pathways [ 48].

This protein activates the alternative complement pathway thereby strengthening unspecific immune defence mechanisms.