Sentence examples for activate the target genes from inspiring English sources

The results show that transcription from different promoters affects the activity of enhancers, counteracting their ability to activate the target genes.

Binding of the Wnt ligands to the membrane frizzled receptor and low-density lipoprotein receptor-related protein 5 and 6 (LRP5/6) co-receptors inhibits GSK-3β, causing the stabilization of β-catenin which then translocates into the nucleus to activate the target genes like T cell factor (TCF) [22].

These proteins then activate the target genes (TG).

Free β-catenin can enter the nucleus and activate the target genes of Wnt.

A similar finding was observed with depleted TFs in the EMT DEGs (Tables  6 and 7), suggesting that many transcription factors are bimodal, i.e., they both inhibit or activate the target genes depending on the chromatin environment.

We concluded that HDAC1 and HDAC8 might cooperate to maximally repress BMF, but HDAC8 de-recruitment alone was sufficient to activate the target gene.

Activation by the CCG/CGC motif is repressed by 10 mM cysteine, and this response is lowered substantially in the absence of VDE, suggesting that VDE binds directly or indirectly to the CCG/CGC motif to activate the target gene.

Chemokine CCL21 binds to its receptor CCR7 to induce the phosphorylation of GLI2 mediated by citron (CIT) kinase, phosphorylation of GLI2 activates the target genes of GLI.

By interacting with diverse co-factors and catalyzing demethylation of mono- and di-methylated H3-K4 or K9, LSD1 is capable of either repressing or activating the target genes.

Upon its activation, p53 will dissociate with mouse double minute 2 homolog (MDM2), an E3 ubiquitin ligase, and translocate to the nucleus, where it activates the target genes.

The phosphorylated STAT gene translocates into the nucleus and activates the target gene (JAK/STAT) pathway.