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The oxidative environment is pivotal in the formation of aromatics to activate the pathways involving the resonantly stabilized radicals in the aromatic growth process.
The additive effect of AZT on these pathways in the presence of SMM suggests that the two treatments activate the pathways by separate mechanisms.
These growth factors bind to receptors on cell membranes and activate the pathways involved in tissue healing.
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This amount increased but activity decreased insulin failed to activate the pathway.
To activate the pathway in neurons, we expressed the constitutively active HEP (hepCA) with the elavGal4 driver.
In contrast, in HEK 293 or NIH 3T3 cells Dkk2 will inhibit a Wnt-Fz signal but activate the pathway, when cotransfected with Lrp5 or -6 (Wu et al., 2000; Li et al., 2002; Mao and Niehrs, 2003).
Mutations in these genes also result in accumulation of Notch protein, but do not activate the pathway [8].
Ciliary localization of Smo is not sufficient to activate the pathway (25).
Finally, it is possible that activating mutation or over-expression of FGFR3 can activate the pathway in UC.
Gorlin's syndrome results from inherited mutations in the Hedgehog receptor PTCH that constitutively activate the pathway.
Various endogenous or immune stimuli can activate the pathway, including LPS, components of the cell wall of gram-negative bacteria.
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