When you wanted to leave, a discreet twist of a knob activated the machinery in reverse, causing the chair, and you, to quietly sink back down, and out.
In organizations, however, complaints almost routinely elicit this response - activating the machinery of denial.
GSK2578215A activates the machinery of mitochondrial dynamics processes, including translocation of Drp-1 from the cytosol to the mitochondria.
We postulate that Mcl-1-deficient GV oocytes activate the autophagic machinery in response to mitochondrial dysfunction accompanied by disruption of metabolic machinery, however, we cannot exclude the possibility that Mcl-1 can directly regulate autophagy.
Mechanistically, these two, albeit distinct, DC functions require active cytoskeleton rearrangements, as membrane protrusions must form to activate the migratory machinery as well as to favor cell∶cell contacts.
We believe that the observed decrease on the transcriptional activity of HIF-1 is, most likely, due to changes on the total amount of the HIF-1α protein, rather than effective decreased activity of HIF-1 to transactivate its target genes and activate the transcriptional machinery.
These, in turn, that activate the cytoskeletal machinery responsible for endocytosis and (possibly) for cell activation responses.
The lack of knowledge is evident, as p53 can also regulate protein expression independent from the direct transcriptional activity i.e. by post-transcriptional regulations and can directly activate the apoptotic machinery at the mitochondrial level [ 13, 26- 31].
These receptors are the main executioners of the "extrinsic" apoptosis pathway that activate the apoptosis machinery by forming a complex called the Death Inducing Signaling Complex (DISC).
