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GW9508 was able to activate the expressions of thermogenic genes (UCP1, PGC-1α, COXIV and Sirt3) in cultured brown adipocytes, but the extent of these inductions were significantly less in FGF21-null cells than in control cells (Fig. 10a).
Under Fe-deficient conditions, AFT1 and AFT2 activate the expressions of vacuolar iron exporter genes, particularly FET5/FTH1 and SMF3; as a result, cytosol iron is increased and vacuolar iron is decreased (Dlouhy and Outten, 2013).
Misexpression of foxi1 is sufficient to activate the expressions of downstream target genes of pax8, dlx3b, dlx4b, and dlx5a in several ectopic sites [26].
The nuclear RelA dimers activate the expressions of pro-inflammatory chemokine and cytokine genes as well as its own inhibitor IκBα, which ensures proper attenuation of inflammatory responses in a negative feedback loop.
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Hence on activation of the ER receptor the Cre-recombinase will activate the expression of GFP.
Transcription factor BMAL1 heterodimerizes with CLOCK to activate the expression of Per and Cry, which in turn suppress CLOCK/BMAL1 activity (Reppert & Weaver, 2002).
However, scientists are also increasingly recognizing that it can be used to activate the expression of genes.
AP4 exclusively forms homodimers, which bind to the E-box motif CAG/CCTG and thereby either repress or activate the expression of target genes.
NLP6 also functions positively in nitrate regulation, is retained in the nucleus in nitrate-treated plants34 and can activate the expression of nitrate-responsive genes47.
Tseng, P.H. et al. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
Kumbrink, J., Kirsch, K.H. & Johnson, J.P. EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.
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