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AP4 exclusively forms homodimers, which bind to the E-box motif CAG/CCTG and thereby either repress or activate the expression of target genes.
Tseng, P.H. et al. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
dCas9-SunTag-VP64 transcriptional system has been reported that it can robustly activate the expression of an endogenous gene using a single guide RNA (sgRNA).
RNA sequencing and ChIP−PCR analyses revealed that JMJD3 exerts anti-AML effect by directly modulating H3K4 and H3K27 methylation levels to activate the expression of a number of key myelopoietic regulatory genes.
El-Brolosy et al.4 and Ma et al.5 report that mutations that lead to the production of truncated, often non-functional proteins indirectly activate the expression of related genes, to provide functional compensation.
Mechanistically, the NF-κb-induced JMJD3 overexpression in T-ALL cells was found to be essentially associated with NOTCH1 to activate the expression of T cell-specific oncogenic target genes.
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These results indicated that deletion fragments did not self-activate the expression of reporter gene URA3.
However, scientists are also increasingly recognizing that it can be used to activate the expression of genes.
Snail also could activate the expression of mesenchymal-like genes to promote cell migration.
Transcription factor BMAL1 heterodimerizes with CLOCK to activate the expression of Per and Cry, which in turn suppress CLOCK/BMAL1 activity (Reppert & Weaver, 2002).
NLP6 also functions positively in nitrate regulation, is retained in the nucleus in nitrate-treated plants34 and can activate the expression of nitrate-responsive genes47.
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