It is known that both stimuli induce apoptosis by activating the cascade of caspases and their substrates.
IL-6 activates the cascade of inflammatory events 17 40 41 and directly amplifies osteoclastogenesis, 15 42 as does TNF.
Application of a mechanical stimulus such as fluid flow shear stress to the bone osteocytes activates the cascade of mechanotransduction mediated by multiple signaling molecules.
It is known that following platelet adhesion and aggregation at the wound site, cytokines are secreted, which activates the cascade of early and late thrombotic complications in patients implanted with coronary stents, including DES.
The study of lauryl gallate (LG) on the pre-B cell lymphoma Wehi 231 line shows that it inhibits PTKs both in crude extracts and whole cells, disrupts the mitochondrial membrane potential, promotes the efflux of cytochrome c to the cytosol, activates the cascade of caspases and induces oligonucleosomal breakdown of DNA (Roy et al, 2000).
The discovery of rheumatoid factors (RFs) by Waaler in 1937 1939 and Rose in 1948 fueled the attractive hypothesis that RA pathogenesis mostly relied on antigen-antibody reactions in the joints, activating the cascade of complement and promoting chemotactic migration of polymorphs, the final effectors of articular damage [ 1].
Similarly, how PHAII-causing mutations of WNK4 activate the cascade remained unelucidated.
A review of studies demonstrates that no less than twelve different brain regions are activated by the cascade of chemicals like dopamine, adrenaline, vasopression, serotonin, and oxytocin when we fall in love.
To further examine whether intracellular signaling of the IR is altered in DOX-treated transgenic rats, we analyzed the phosphorylation state of the Akt protein, a Ser/Thr kinase activated through the cascade of reactions initiated by the IR after insulin binding.
