Sentence examples for activate targets from inspiring English sources
New developments in DBS are focusing on enabling directional stimulation capabilities that may possibly activate targets with greater specificity.
Initially we compared the ability of insulin to activate targets located downstream of Akt in soleus muscle.
Altogether 104 regulators only activate targets but 841 regulators only repress targets; 485 regulators both repress and activate targets.
In this way genes, which appear to be amplified, with correlated increases in expression, would actually have reduced levels of their proteins to activate targets, thus giving the impression of repression.
In vertebrates, the specialization of various STAT proteins for different binding sites might have been advantageous for acquiring target specificity (Seidel et al, 1995), although it is possible that vertebrate STATs can also activate targets through low binding affinity sites.
In support of this observation our mosaic analysis with a repressible cell marker (MARCM) experiments in the developing wing disc showed that overexpression of Myc partially rescues the growth disadvantage of clones mutant for the hypomorphic Rheb 7A1 allele (Additional file 8), further supporting the idea that Myc acts downstream of TOR to activate targets that control growth in these clones.
STATs are cytosolic proteins that, upon activation, translocate in to the nucleus to activate target genes.
Similarly, Gilbert et al. fused dCas9 to the activation domains of either VP64 or p65 to activate targeted genes (Gilbert et al. 2013).
Early studies suggested that specificity is dictated by sets of differentially induced transcription factors that synergistically activate target genes containing their binding sites.
In response to specific metabolic signals, protein kinases phosphorylate and activate target proteins that amplify the signal into cellular growth cascades.
Words like "activate," "targeted" and "key markets" sometimes pop out of Calderin's mouth – evidence of his job in marketing and branding for Burton Snowboards.
