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However, in the presence of GSH, PDI can activate sufficient Ero1α to maintain activity, presumably because GSH can continually reduce PDI.
This difference between rTMS effects could simply be because subthreshold rTMS failed to activate sufficient neurones to produce interference, or it could indicate an important role for re-afferent feedback from the movements evoked by suprathreshold stimulation.
However, TNFα alone does not activate sufficient amounts of these proteins to induce cytochrome c release in the sensitizing model and therefore does not result in any caspase-3 activation.
Under physiological conditions, activated healthy platelets release enough cargo to activate sufficient number of their counterparts and promote stabilization of the haemostatic plug that will prevent excessive bleeding.
The most likely explanation for this is that linopirdine depolarized the PASMC, thereby facilitating the effects of hypoxia, but the depolarization was too small by itself to activate sufficient Ca2+ influx for contraction (5).
As shown in Figure 3A, at 100 n M, either of the enzymes with either cofactor could activate sufficient CB1954 to kill all the cells, but below 10 n M enzyme, only NfsA achieved significant toxicity, and that required NADPH as a cofactor.
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However, TNFα activates sufficient caspase-8 via complex2 to cleave some Bid molecules.
This parameterization guarantees that Fas ligand is activating sufficient caspase-3 in the model to overcome the XIAP buffer but not inducing cytochrome c release and TNFα does not lead to significant caspase-3 activation.
Of the eight patients who had suffered tumor reoccurrence within 7 months, three were also accurately predicted by APOPTO-CELL as being incapable of activating sufficient levels of executioner caspases.
We assumed that each cell is exposed to enough ligand in order to activate a sufficient number of receptors for signal propagation.
Thus the endogenous potential of procoagulant activators was sufficient to activate fibrinogen and to terminate bleeding.
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