Sentence examples for activate smooth from inspiring English sources

Because also of the ability to activate smooth muscle PPARγ to induce relaxation, Wy14643 offers additional protection against vascular dysfunction of spontaneous hypertension.

Generation of sphingolipid metabolites such as ceramide, sphingosine, and sphingosine-1-phosphate can activate smooth muscle cell proliferation, endothelial cell differentiation, apoptosis and cell death, migration, vasoconstriction, and dilation.

This study [25] also shows that miR-145 is activating one of its direct targets, the myocardin (Myocd), which is a transcription factor well known to activate smooth muscle gene expression by interacting with SRF [26].

We previously showed that lithocholic acid (LC) and other cholane derivatives activated smooth muscle BK channels and, thus, caused endothelium-independent cerebral artery dilation.

When the liver is injured by infection or toxins like alcohol, it repairs the damage by activating smooth, muscular liver cells.

Hyperpolarization is also initiated via K+ in the localized myoendothelial space activating smooth muscle Na+/K+ATPase, whilst endothelial cell inward rectifying potassium channels (Kir) may be involved in amplifying the response [13].

Myocardin, a potent serum response factor (SRF) coactivator expressed in cardiac and smooth muscle cells, activates smooth muscle genes [ 20- 22].

Furthermore, IL-4Rα-mediated signalling activates smooth muscle cells, leading to hypercontractibility during infection, while also stimulating Th2-promoting cytokine production from muscle cells [ 44].

Our results show upregulation of TGF-β signalling pathways and vessel wall fibrosis in the systemic arterial circulation, altered vasoreactivity, and a TGF-β activated smooth muscle cell phenotype with additional perturbation of endothelin axis signaling.

In the development of atherosclerosis, activated smooth muscle cells in the medial layer of arteries migrate to the atherosclerotic fatty streaks in the intimal layer and produce an extensive extracellular matrix.

Numerous endogenous vasodilators activate vascular smooth muscle KATP channels through adenylate cyclase and PKA phosphorylation.