Sentence examples for activate signal from inspiring English sources
Leptin and amylin alone and in combination activate signal transducer and activator of transcription 3 (STAMP-activatedivated protein kinase, Akt, and extracellular signal-regulated kinase signaling pathways in hAT ex vivo and hPAs and hPBMCs in vitro; all phosphorylation events were saturable at leptin and amylin concentrations of ∼50 and ∼20 ng/ml, respectively.
Moreover, the receptors bind and activate signal transducers and activators of transcription (STATs), which after activation are translocated to the nucleus where they act as transcription factors.
It is well-documented that JAK kinases play a pivotal role in cytokine receptor signaling to phosphorylate and activate signal transducer and activator of transcription (STAT) proteins.
The induction of lineage-specifying transcription factors is initiated by cytokines that signal through receptors to activate signal transducer and activator and transcription (STAT) family members, thereby directly linking the cytokine environment to transcriptional regulation.
IL-4 uses Janus kinases (JAKs) to initiate the signaling cascade and activate signal transducer and activator of transcription 6 (STAT6), consequently modulating allergic airway inflammation in asthma and other diseases [ 1].
In addition, type I IFNs activate signal transducers and activators of transcription 3 (STAT3) which in turn inhibits STAT1-dependent gene activation and thereby downregulates the activities of immune inflammatory mediators in myeloid cells [ 213].
In summary, our results suggest that HDL and SR-BI have pro-oncogenic activity and can induce migration and activate signal-transduction pathways responsible for cellular proliferation and tumor formation in two breast cancer cell lines.
Integrin-extracellular matrix interactions also activate signaling cascades such as mitogen activated protein kinases [ 2].
Wnt1 was used to activate signaling at the extracellular level.
In contrast, low amounts of AR are sufficient to activate signaling transducing effectors [4].
In this form, SRs are prevalently localized in the cytoplasm, where they activate signaling cascades.
