Sentence examples for activate pathways from inspiring English sources

Caspase-9 and caspase 3, which are downregulated upon PKB/Akt activation, fail to activate pathways leading to apoptosis [ 19].

However, the regulation of collections of genes that act in concert (gene sets) to activate pathways, or respond to activation of a pathway, might be expected to be more similar (Subramanian et al., 2005).

The cells respond to extra- and intra-cellular signals by dynamic orchestration of activities of pathways in the networks; activate pathways that are needed and inactivate the others [2].

In contrast to the activation of survival/proliferative pathways by UDCA, butyrate was found to activate pathways known to mediate cell death by apoptosis, namely PKC- δ and p38 MAP kinase, consistent with the induction of apoptosis by this agent (Hague et al, 1993; McMillan et al, 2000).

Alternatively, or in addition, prolonged activation of Ire-1 in the fly retina during eye development may activate pathways that, in turn, induce cell death (29).

Jane Stewart of Concordia University in Montreal, Canada, who studies the involvement of CRH receptors in addictive behavior, explains that "the stress may activate pathways that have nothing directly to do with fear and anxiety but which alter the approach to alcohol itself".

The three Hh ligands (Sonic, Indian and Desert) activate pathway signaling by binding to the cell surface receptor Patched (PTCH).

The PI3-kinase pathway is one of the most commonly activated pathways in cancer and the focus of intense effort to capitalize on its therapeutic potential.

In order to maintain persistence, HCV is able to suppress UPR by inhibiting several nodes of UPR activating pathways [79].

These findings suggest that hypoxia guides macrophage behavior to a pro-angiogenic phenotype via IL-10 activated pathways.

Restoration of replication competence activated pathways involved in processing and presentation of HIV and poxvirus antigens to T cells.